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KMID : 0043320210440050475
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Archives of Pharmacal Research
2021 Volume.44 No. 5 p.475 ~ p.486
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Structural feature of TRAFs, their related human diseases and therapeutic intervention
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Park Hyun-Ho
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Abstract
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Several studies have been conducted over the years to unravel the structural information on the receptors that bind to tumor necrosis factor receptor-associated factor (TRAF) and the driving forces for the TRAF/receptor complex. In addition, studies have also been performed to highlight the influence of TRAF malfunctioning and mutations on the development of human disease. However, a holistic study that systematically summarizes the available information and the existing clinical trends towards development of the TRAF-targeting drugs has not been conducted to date. Herein, I reviewed existing research that focused on the structural information of various receptors recognized by the different members of the TRAF family. I also reviewed studies on the different human diseases that occur due to TRAF malfunctioning or mutations as well as the clinical trials undertaken to treat TRAF-associated diseases.
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KEYWORD
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Innate immunity, TRAF family, TRAF domain, TRAF-associated diseases, Structure-based drug design
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